产品详情
简单介绍：
Anti-TriMethyl-Histone H3-K9 Antibody
详情介绍：
Overview
| Name: | Anti-TriMethyl-Histone H3-K9 Antibody See all H3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to TriMethyl-Histone H3-K9. |
| Applications: | WB, IHC, IF, IP, ChIP, ChIPseq |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:200, ChIP: 1:50 - 1:200, ChIP seq: 1:50 - 1:200. |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic methylated peptide corresponding to residues surrounding K9 of human histone H3. |
| Protein Length: | 136 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Tissue Specificity: | Expressed in testicular cells. |
| Sequence Similarities: | Belongs to the histone H3 family. |
| Post-Translational Modification: | Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity). |
| Cellular Location: | Nucleus. Chromosome. |
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