产品详情
简单介绍：
Anti-Cytokeratin 18 Antibody
详情介绍：
Overview
| Name: | Anti-Cytokeratin 18 Antibody See all Cytokeratin 18 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Cytokeratin 18 |
| Specificity: | Cytokeratin 18 Polyclonal Antibody detects endogenous levels of Cytokeratin 18 protein. |
| Applications: | WB, IHC, IP, IF, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human Cytokeratin 18 around the non-phosphorylation site of S33. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1mg / ml |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20?C / 1 year |
Target
| Function: | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Tissue Specificity: | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
| Involvement in Disease: | Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. |
| Sequence Similarities: | Belongs to the intermediate filament family. |
| Post-Translational Modification: | Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. |
| Cellular Location: | Cytoplasm > Perinuclear region. Nucleus > Nucleolus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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