产品详情
简单介绍：
Anti-D-3-phosphoglycerate dehydrogenase Antibody
详情介绍：
Overview
| Name: | Anti-D-3-phosphoglycerate dehydrogenase Antibody See all D-3-phosphoglycerate dehydrogenase primary antibodies
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| Description: | Rabbit polyclonal antibody to D-3-phosphoglycerate dehydrogenase |
| Specificity: | The antibody detects endogenous level of total D-3-phosphoglycerate dehydrogenase polyclonal antibody. |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Recombinant human D-3-phosphoglycerate dehydrogenase protein |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Caprylic Acid Ammonium Sulfate Precipitation purified |
| Concentration: | 1.0mg / mL |
| Formulation: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Storage: | Store at -20?C |
Target
| Function: | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. |
| Involvement in Disease: | Phosphoglycerate dehydrogenase deficiency: An autosomal recessive inborn error of L-serine biosynthesis, clinically characterized by congenital microcephaly, psychomotor retardation, and seizures. Neu-Laxova syndrome 1: A lethal, autosomal recessive multiple malformation syndrome characterized by ichthyosis, marked intrauterine growth restriction, microcephaly, short neck, limb deformities, hypoplastic lungs, edema, and central nervous system anomalies including lissencephaly, cerebellar hypoplasia and/or abnormal/agenesis of the corpus callosum. Abnormal facial features include severe proptosis with ectropion, hypertelorism, micrognathia, flattened nose, and malformed ears. |
| Sequence Similarities: | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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