产品详情
简单介绍：
Anti-DDIT4 Antibody
详情介绍：
Overview
| Name: | Anti-DDIT4 Antibody See all DDIT4 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DDIT4 |
| Specificity: | The antibody detects endogenous levels of total DDIT4 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Full length fusion protein |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 1.5mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. |
| Tissue Specificity: | Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). |
| Sequence Similarities: | Belongs to the DDIT4 family. |
| Post-Translational Modification: | Phosphorylated by GSK3B; this promotes proteasomal degradation. |
| Cellular Location: | Mitochondrion. Cytoplasm > Cytosol. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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