产品详情
简单介绍：
Anti-DDX4 Antibody
详情介绍：
Overview
| Name: | Anti-DDX4 Antibody See all DDX4 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DDX4 |
| Specificity: | The antibody detects endogenous levels of total DDX4 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to a region derived from internal residues of human DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 0.7mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Probable ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). |
| Tissue Specificity: | Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes. |
| Sequence Similarities: | Belongs to the DEAD box helicase family. DDX4/VASA subfamily. |
| Cellular Location: | Cytoplasm. Cytoplasm > Perinuclear region. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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