产品详情
简单介绍：
Anti-DGK-θ (S725) Antibody
详情介绍：
Overview
| Name: | Anti-DGK-θ (S725) Antibody See all DGK-θ primary antibodies
|
| Description: | Rabbit polyclonal antibody to DGK-θ (S725) |
| Specificity: | Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphati |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide, corresponding to amino acids 700-750 of Human DGK-θ. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 101 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Target
| Function: | Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. |
| Sequence Similarities: | Belongs to the eukaryotic diacylglycerol kinase family. |
| Post-Translational Modification: | Phosphorylated by PRKCE and PRKCH in vitro. |
| Cellular Location: | Cytoplasm. Cell membrane. Cytoplasm > Cytoskeleton. Nucleus. Nucleus speckle. Translocates to the nucleus in response to thrombin stimulation (PubMed:15632189). Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189). |
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