产品详情
简单介绍：
Anti-DGKH Antibody
详情介绍：
Overview
| Name: | Anti-DGKH Antibody See all DGKH primary antibodies
|
| Description: | Rabbit polyclonal antibody to DGKH |
| Specificity: | The antibody detects endogenous levels of total DGKH protein |
| Applications: | IHC, IF |
| Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human DGKH. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1.0mg / ml |
| Formulation: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. |
| Tissue Specificity: | Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon. |
| Sequence Similarities: | Belongs to the eukaryotic diacylglycerol kinase family. |
| Post-Translational Modification: | Phosphorylated; does not inhibit catalytic activity. |
| Cellular Location: | Cytoplasm. Cell membrane. Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016). |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
