产品详情
简单介绍：
Anti-DKK3 Antibody
详情介绍：
Overview
| Name: | Anti-DKK3 Antibody See all DKK3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DKK3 |
| Specificity: | DKK3 pAb detects endogenous levels of DKK3 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant full length Human DKK3. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~38 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol. |
Target
| Function: | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
| Tissue Specificity: | Highest expression in heart, brain, and spinal cord. |
| Sequence Similarities: | Belongs to the dickkopf family. |
| Post-Translational Modification: | N- and O-glycosylated. |
| Cellular Location: | Secreted. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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