产品详情
简单介绍：
Anti-DNAJA3 Antibody
详情介绍：
Overview
| Name: | Anti-DNAJA3 Antibody See all DNAJA3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DNAJA3. |
| Applications: | WB, IHC, IF |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100. |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of human DNAJA3. |
| Protein Length: | 480 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Tissue Specificity: | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. |
| Post-Translational Modification: | Tyrosine phosphorylated. |
| Cellular Location: | Mitochondrion matrix. Cytoplasm > Cytosol. Cell junction > Synapse > Postsynaptic cell membrane. Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. |
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