产品详情
简单介绍：
Anti-DOK1 Antibody
详情介绍：
Overview
| Name: | Anti-DOK1 Antibody See all DOK1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DOK1 |
| Applications: | E, WB, ICC |
| Reactivity: | Human |
| Immunogen: | Raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity chromatography purified via peptide column |
| Formulation: | Supplied in PBS containing 0.02% sodium azide. |
| Storage: | Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Target
| Function: | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same on ITGB3. |
| Tissue Specificity: | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. |
| Sequence Similarities: | Belongs to the DOK family. Type A subfamily. |
| Post-Translational Modification: | Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. |
| Cellular Location: | Cytoplasm. Nucleus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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