产品详情
简单介绍：
Anti-DOK2 Antibody
详情介绍：
Overview
| Name: | Anti-DOK2 Antibody See all DOK2 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DOK2 |
| Specificity: | The antibody detects endogenous levels of total DOK2 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide of human DOK2 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification |
| Concentration: | 0.4mg / ml |
| Formulation: | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). |
| Tissue Specificity: | Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. |
| Sequence Similarities: | Belongs to the DOK family. Type A subfamily. |
| Post-Translational Modification: | On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity). |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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