产品详情
简单介绍：
Anti-DR5 Antibody
详情介绍：
Overview
| Name: | Anti-DR5 Antibody See all DR5 primary antibodies
|
| Description: | Mouse monoclonal antibody to DR5 |
| Specificity: | This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins. |
| Applications: | WB, ICC |
| Dilutions: | Western blotting: 1:500-1:2000 |
| Reactivity: | Human, Mouse |
| Immunogen: | Purified recombinant human TNFRSF10B protein fragments expressed in E.coli. |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Unconjugated |
| Purification: | Affinity purified |
| Formulation: | Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg / mlBSA and 50% glycerol. |
| Storage: | store at -20˚C |
Target
| Function: | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Tissue Specificity: | Widely expressed in ***** and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. |
| Involvement in Disease: | Squamous cell carcinoma of the head and neck: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. |
| Cellular Location: | Membrane. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
