产品详情
简单介绍：
Anti-DR5 Antibody
详情介绍：
Overview
| Name: | Anti-DR5 Antibody See all DR5 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DR5 |
| Specificity: | Antibody has no cross reaction to DR4. |
| Applications: | E, WB, ICC |
| Reactivity: | Human, Mouse |
| Immunogen: | Raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity chromatography purified via peptide column |
| Formulation: | Supplied in PBS containing 0.02% sodium azide. |
| Storage: | Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Target
| Function: | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis (By similarity). |
| Tissue Specificity: | Highly expressed in heart, lung and kidney. |
| Cellular Location: | Membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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