产品详情
简单介绍：
Anti-DRD3 Antibody
详情介绍：
Overview
| Name: | Anti-DRD3 Antibody See all DRD3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DRD3 |
| Specificity: | The antibody detects endogenous level of total DRD3 antibody. |
| Applications: | WB, IF |
| Reactivity: | Human |
| Immunogen: | Recombinant protein of human DRD3. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antibodies were purified by affinity purification using immunogen. |
| Concentration: | 1.0mg / ml |
| Formulation: | Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20˚C |
Target
| Function: | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. |
| Tissue Specificity: | Brain. |
| Involvement in Disease: | Tremor, hereditary essential 1: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. |
| Sequence Similarities: | Belongs to the G-protein coupled receptor 1 family. |
| Post-Translational Modification: | Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma). |
| Cellular Location: | Cell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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