产品详情
简单介绍：
Anti-DUSP26 Antibody
详情介绍：
Overview
| Name: | Anti-DUSP26 Antibody See all DUSP26 primary antibodies
|
| Description: | Rabbit polyclonal antibody to DUSP26 |
| Specificity: | The antibody detects endogenous levels of total DUSP26 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to residues near the C terminal of human dual specificity phosphatase 26 (putative) |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 2.8mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
| Tissue Specificity: | Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. |
| Sequence Similarities: | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. |
| Cellular Location: | Cytoplasm. Nucleus. Golgi apparatus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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