产品详情
简单介绍：
Anti-EBI3 Antibody
详情介绍：
Overview
| Name: | Anti-EBI3 Antibody See all EBI3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EBI3 |
| Applications: | E, WB, IHC |
| Reactivity: | Human, Mouse |
| Immunogen: | Raised against a 16 amino acid peptide from near the carboxy terminus of human EBI3. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity chromatography purified via peptide column |
| Formulation: | Supplied in PBS containing 0.02% sodium azide. |
| Storage: | Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Target
| Function: | Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. |
| Sequence Similarities: | Belongs to the type I cytokine receptor family. Type 3 subfamily. |
| Cellular Location: | Secreted. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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