产品详情
简单介绍：
Anti-ECM1 Antibody
详情介绍：
Overview
| Name: | Anti-ECM1 Antibody See all ECM1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to ECM1 |
| Specificity: | The antibody detects endogenous levels of total ECM1 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ECM1 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 1.8mg / ml |
| Formulation: | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. |
| Tissue Specificity: | Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis. |
| Involvement in Disease: | Lipoid proteinosis: Rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. |
| Cellular Location: | Secreted > Extracellular space > Extracellular matrix. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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