产品详情
简单介绍：
Anti-EDN3 Antibody
详情介绍：
Overview
| Name: | Anti-EDN3 Antibody See all EDN3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EDN3 |
| Specificity: | The antibody detects endogenous levels of total EDN3 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to a region derived from internal residues of human endothelin 3 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 1.2mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Endothelins are endothelium-derived vasoconstrictor peptides. |
| Tissue Specificity: | Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells. |
| Involvement in Disease: | Hirschsprung disease 4: A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. Congenital central hypoventilation syndrome: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Waardenburg syndrome 4B: A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). |
| Sequence Similarities: | Belongs to the endothelin/sarafotoxin family. |
| Cellular Location: | Secreted. |
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