产品详情
简单介绍：
Anti-EDNRB Antibody
详情介绍：
Overview
| Name: | Anti-EDNRB Antibody See all EDNRB primary antibodies
|
| Description: | Rabbit polyclonal antibody to EDNRB |
| Specificity: | EDNRB pAb detects endogenous levels of EDNRB protein. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Immunogen: | Recombinant full length Human EDNRB. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~50 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol. |
Target
| Function: | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Tissue Specificity: | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. |
| Involvement in Disease: | Waardenburg syndrome 4A: A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). Hirschsprung disease 2: A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child. ABCD syndrome: An autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine. |
| Sequence Similarities: | Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. |
| Post-Translational Modification: | Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. |
| Cellular Location: | Cell membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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