产品详情
简单介绍：
Anti-eEF2K Antibody
详情介绍：
Overview
| Name: | Anti-eEF2K Antibody See all eEF2K primary antibodies
|
| Description: | Rabbit polyclonal antibody to eEF2K |
| Specificity: | eEF2K Polyclonal Antibody detects endogenous levels of eEF2K protein. |
| Applications: | WB, IHC, ELISA |
| Reactivity: | Human, Rat |
| Immunogen: | Synthesized peptide derived from human eEF2K around the non-phosphorylation site of S366. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1mg / ml |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20?C / 1 year |
Target
| Function: | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. |
| Sequence Similarities: | Belongs to the protein kinase superfamily. Alpha-type protein kinase family. |
| Post-Translational Modification: | Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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