产品详情
简单介绍：
Anti-EFCAB4B Antibody
详情介绍：
Overview
| Name: | Anti-EFCAB4B Antibody See all EFCAB4B primary antibodies
|
| Description: | Rabbit polyclonal antibody to EFCAB4B |
| Applications: | E, WB, IHC |
| Reactivity: | Human, Mouse |
| Immunogen: | Raised against a 14 amino acid peptide near the carboxy terminus of human EFCAB4B. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity chromatography purified via peptide column |
| Formulation: | Supplied in PBS containing 0.02% sodium azide. |
| Storage: | Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Target
| Function: | Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity). |
| Sequence Similarities: | Belongs to the EFCAB4 family. |
| Cellular Location: | Cytoplasm. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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