产品详情
简单介绍：
Anti-EFP (D222) Antibody
详情介绍：
Overview
| Name: | Anti-EFP (D222) Antibody See all EFP primary antibodies
|
| Description: | Rabbit polyclonal antibody to EFP (D222) |
| Specificity: | EFP (D222) pAb detects endogenous levels of EFP protein. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide, corresponding to amino acids 360-418 of Human EFP. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 71 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Target
| Function: | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). |
| Tissue Specificity: | Expressed in breast tumors (at protein level). Ubiquitous. |
| Post-Translational Modification: | Auto-ISGylated. |
| Cellular Location: | Cytoplasm. Colocalized with DDX58 at cytoplasmic perinuclear bodies. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
