产品详情
简单介绍：
Anti-EIF4EBP1 Antibody
详情介绍：
Overview
| Name: | Anti-EIF4EBP1 Antibody See all EIF4EBP1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EIF4EBP1 |
| Specificity: | The antibody detects endogenous levels of total EIF4EBP1 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to residues near the N terminal of human eukaryotic translation initiation factor 4E binding protein 1 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 2mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| Sequence Similarities: | Belongs to the eIF4E-binding protein family. |
| Post-Translational Modification: | Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
