产品详情
简单介绍：
Anti-ELAC2 Antibody
详情介绍：
Overview
| Name: | Anti-ELAC2 Antibody See all ELAC2 primary antibodies
|
| Description: | Rabbit polyclonal antibody to ELAC2 |
| Specificity: | The antibody detects endogenous levels of total ELAC2 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to residues near the C terminal of human elaC ribonuclease Z 2 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 1.5mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. |
| Tissue Specificity: | Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes. |
| Involvement in Disease: | Prostate cancer, hereditary, 2: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Combined oxidative phosphorylation deficiency 17: An autosomal recessive disorder of mitochondrial dysfunction characterized by onset of severe hypertrophic cardiomyopathy in the first year of life. Other features include hypotonia, poor growth, lactic acidosis, and failure to thrive. The disorder may be fatal in early childhood. |
| Sequence Similarities: | Belongs to the RNase Z family. |
| Cellular Location: | Mitochondrion. Nucleus. Mainly mitochondrial. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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