产品详情
简单介绍：
Anti-Elk1 (Phospho-Thr417) Antibody
详情介绍：
Overview
| Name: | Anti-Elk1 (Phospho-Thr417) Antibody See all Elk1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Elk1 (Phospho-Thr417) |
| Specificity: | The antibody detects endogenous level of Elk1 only when phosphorylated at threonine 417. |
| Applications: | IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Peptide sequence around phosphorylation site of threonine 417(L-S-T(p)-P-V) derived from Human Elk1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Concentration: | 1.0mg / ml |
| Predicted MW: | 47kd |
| Formulation: | Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20°C |
Target
| Function: | Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). |
| Tissue Specificity: | Lung and testis. |
| Sequence Similarities: | Belongs to the ETS family. |
| Post-Translational Modification: | Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. |
| Cellular Location: | Nucleus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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