产品详情
简单介绍：
Anti-ELMO2 Antibody
详情介绍：
Overview
| Name: | Anti-ELMO2 Antibody See all ELMO2 primary antibodies
|
| Description: | Goat polyclonal antibody to ELMO2. |
| Applications: | ELISA, WB, IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide corresponding to Human ELMO2 (C terminal). |
| Sequence: | C-PKEPSSYDFVYHYG |
| Host: | Goat |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 100 μg at 0.5 mg/ml. |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Tissue Specificity: | Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. |
| Involvement in Disease: | Vascular malformation, primary intraosseous: A rare malformation characterized by non-neoplastic severe expansions of blood vessels, usually seen in the vertebral column and in the skull. The most commonly affected bones in the skull are the mandible and the maxilla, and life-threatening bleeding after a simple tooth extraction is frequently observed. Inheritance is autosomal recessive. |
| Cellular Location: | Cytoplasm. Cytoplasm > Cytosol. Membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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