产品详情
简单介绍：
Anti-ELOVL5 Antibody
详情介绍：
Overview
| Name: | Anti-ELOVL5 Antibody See all ELOVL5 primary antibodies
|
| Description: | Rabbit polyclonal antibody to ELOVL5 |
| Specificity: | The antibody detects endogenous levels of total ELOVL5 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human ELOVL5. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1.0mg / ml |
| Formulation: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
| Tissue Specificity: | Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. |
| Involvement in Disease: | Spinocerebellar ataxia 38: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA38 is an autosomal dominant form characterized by *****-onset of slowly progressive gait ataxia accompanied by nystagmus. Brain MRI shows cerebellar atrophy. |
| Sequence Similarities: | Belongs to the ELO family. ELOVL5 subfamily. |
| Cellular Location: | Endoplasmic reticulum membrane. Cell projection > Dendrite. In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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