产品详情
简单介绍：
Anti-EMAP II Antibody
详情介绍：
Overview
| Name: | Anti-EMAP II Antibody See all EMAP II primary antibodies
|
| Description: | Rabbit polyclonal antibody to EMAP II |
| Applications: | WB, IF |
| Reactivity: | Human |
| Immunogen: | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 233 of EMAP II |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Purified by antigen-affinity chromatography. |
| Formulation: | Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. |
| Storage: | Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use. |
Target
| Function: | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. |
| Involvement in Disease: | Leukodystrophy, hypomyelinating, 3: A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system. |
| Post-Translational Modification: | Cleaved by caspase-7 in response to apoptosis to produce EMAP-II. |
| Cellular Location: | Nucleus. Cytoplasm > Cytosol. Cytoplasmic vesicle > Secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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