产品详情
简单介绍：
Anti-ENC-2 Antibody
详情介绍：
Overview
| Name: | Anti-ENC-2 Antibody See all ENC-2 primary antibodies
|
| Description: | Chicken polyclonal antibody to ENC-2 |
| Applications: | E, WB, ICC |
| Reactivity: | Human |
| Immunogen: | Raised against a 14 amino acid peptide near the center of human ENC-2. |
| Host: | Chicken |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity chromatography purified via peptide column |
| Formulation: | Supplied in PBS containing 0.02% sodium azide. |
| Storage: | Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Target
| Function: | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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