产品详情
简单介绍：
Anti-ENC1 Antibody
详情介绍：
Overview
| Name: | Anti-ENC1 Antibody See all ENC1 primary antibodies
|
| Description: | Goat polyclonal antibody to ENC1. |
| Applications: | ELISA, WB, IHC |
| Reactivity: | Rat, Human |
| Immunogen: | Synthetic peptide corresponding to Human ENC1 (internal region). |
| Sequence: | TSVSHDKLPKVQC |
| Host: | Goat |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 100 μg at 0.5 mg/ml. |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. |
| Tissue Specificity: | Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in ***** brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in ***** pancreas. May be down-regulated in neuroblastoma tumors. |
| Post-Translational Modification: | Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. |
| Cellular Location: | Nucleus matrix. Cytoplasm. Cytoplasm > Cytoskeleton. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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