产品详情
简单介绍：
Anti-Endothelin 1 Antibody
详情介绍：
Overview
| Name: | Anti-Endothelin 1 Antibody See all Endothelin 1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Endothelin 1 |
| Applications: | WB, IF |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide contain a sequence corresponding to a region within amino acids 141 and 203 of Human EDN1 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Purified by antigen-affinity chromatography. |
| Formulation: | Supplied in 0.1M Tris-buffered saline with 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. |
| Storage: | Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use. |
Target
| Function: | Endothelins are endothelium-derived vasoconstrictor peptides. |
| Tissue Specificity: | Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. |
| Involvement in Disease: | Question mark ears, isolated: An auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus. Auriculocondylar syndrome 3: A craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. |
| Sequence Similarities: | Belongs to the endothelin/sarafotoxin family. |
| Cellular Location: | Secreted. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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