产品详情
简单介绍：
Anti-ENPP2 Antibody
详情介绍：
Overview
| Name: | Anti-ENPP2 Antibody See all ENPP2 primary antibodies
|
| Description: | Rabbit polyclonal antibody to ENPP2 |
| Specificity: | The antibody detects endogenous levels of total ENPP2 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ENPP2 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification |
| Concentration: | 0.9mg / ml |
| Formulation: | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. |
| Tissue Specificity: | Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues. |
| Sequence Similarities: | Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. |
| Post-Translational Modification: | N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. |
| Cellular Location: | Secreted. Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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