产品详情
简单介绍：
Anti-EPHA1 Antibody
详情介绍：
Overview
| Name: | Anti-EPHA1 Antibody See all EPHA1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EPHA1. |
| Applications: | WB, IHC, IF |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200. |
| Reactivity: | Human |
| Immunogen: | Recombinant protein of human EPHA1. |
| Protein Length: | 976 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. |
| Tissue Specificity: | Overexpressed in several carcinomas. |
| Sequence Similarities: | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| Post-Translational Modification: | Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. |
| Cellular Location: | Cell membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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