产品详情
简单介绍：
Anti-EPHA1Antibody Antibody
详情介绍：
Overview
| Name: | Anti-EPHA1Antibody Antibody See all EPHA1Antibody primary antibodies
|
| Description: | Rabbit polyclonal antibody to EPHA1Antibody |
| Specificity: | The antibody detects endogenous levels of total EPHA1protein. |
| Applications: | WB, IF |
| Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human EPHA1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1.0mg / ml |
| Formulation: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20˚C |
Target
| Function: | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. |
| Tissue Specificity: | Overexpressed in several carcinomas. |
| Sequence Similarities: | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| Post-Translational Modification: | Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. |
| Cellular Location: | Cell membrane. |
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