产品详情
简单介绍：
Anti-EPHA3 Antibody
详情介绍：
Overview
| Name: | Anti-EPHA3 Antibody See all EPHA3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EPHA3. |
| Applications: | WB |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200. |
| Reactivity: | Human, Mouse |
| Immunogen: | Recombinant protein of human EPHA3. |
| Protein Length: | 983 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| Tissue Specificity: | Widely expressed. Highest level in placenta. |
| Involvement in Disease: | Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. |
| Sequence Similarities: | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| Post-Translational Modification: | Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. |
| Cellular Location: | Cell membrane. |
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