产品详情
简单介绍：
Anti-EphB1 / 2 (Phospho-Tyr594 / 604) Antibody
详情介绍：
Overview
| Name: | Anti-EphB1 / 2 (Phospho-Tyr594 / 604) Antibody See all EphB1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EphB1 / 2 (Phospho-Tyr594 / 604) |
| Specificity: | Phospho-EphB1 / 2 (Y594 / 604) Polyclonal Antibody detects endogenous levels of EphB1 / 2 protein only when phosphorylated at Y594 / 604. |
| Applications: | WB, IF, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human EphB1 / 2 around the phosphorylation site of Y594 / 604. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1mg / ml |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20˚C / 1 year |
Target
| Function: | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the ***** nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. |
| Tissue Specificity: | Preferentially expressed in brain. |
| Sequence Similarities: | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| Post-Translational Modification: | Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL. |
| Cellular Location: | Cell membrane. Early endosome membrane. Cell projection > Dendrite. |
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