产品详情
简单介绍：
Anti-EPHB3 Antibody
详情介绍：
Overview
| Name: | Anti-EPHB3 Antibody See all EPHB3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EPHB3 |
| Specificity: | The antibody detects endogenous levels of total EPHB3 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide corresponding to a region derived from internal residues of human EPH receptor B3 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 1.5mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. |
| Tissue Specificity: | Ubiquitous. |
| Sequence Similarities: | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| Post-Translational Modification: | Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-614 is required for interaction with SH2 domain-containing proteins. |
| Cellular Location: | Cell membrane. Cell projection > Dendrite. |
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