产品详情
简单介绍：
Anti-EPHB4 Antibody
详情介绍：
Overview
| Name: | Anti-EPHB4 Antibody See all EPHB4 primary antibodies
|
| Description: | Rabbit polyclonal antibody to EPHB4 |
| Specificity: | The antibody detects endogenous levels of total EPHB4 protein. |
| Applications: | IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide of human EPHB4 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 1.5mg / ml |
| Formulation: | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. |
| Tissue Specificity: | Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. |
| Sequence Similarities: | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| Post-Translational Modification: | Phosphorylated; autophosphorylation is stimulated by EFNB2. |
| Cellular Location: | Cell membrane. |
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