产品详情
简单介绍：
Anti-Ephrin-B2 (Ab-330) Antibody
详情介绍：
Overview
| Name: | Anti-Ephrin-B2 (Ab-330) Antibody See all Ephrin-B2 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Ephrin-B2 (Ab-330) |
| Specificity: | The antibody detects endogenous level of total Ephrin-B2 protein. |
| Applications: | WB, IF |
| Dilutions: | Western blotting: 1:500~1:1000 Immunofluorescence: 1:100~1:200 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Peptide sequence around aa.328~332 (N-I-Y-Y-K) derived from Human Ephrin B (ephrin-B2). |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Concentration: | 1.0mg / ml |
| Predicted MW: | 37kd |
| Formulation: | Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: | Store at -20°C for long term preservation (recommended). Store at 4°C for short term use. |
Target
| Function: | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. |
| Tissue Specificity: | Lung and kidney. |
| Sequence Similarities: | Belongs to the ephrin family. |
| Post-Translational Modification: | Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. |
| Cellular Location: | Membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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