产品详情
简单介绍：
Anti-Eps15 Antibody
详情介绍：
Overview
| Name: | Anti-Eps15 Antibody See all Eps15 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Eps15 |
| Specificity: | The antibody detects endogenous levels of total Eps15 protein. |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide corresponding to a region within amino acids 832 and 896 of Eps15. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antibodies were purified by antigen-affinity chromatography. |
| Concentration: | 0.83mg / ml |
| Formulation: | Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage: | Store at -20˚C |
Target
| Function: | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
| Tissue Specificity: | Ubiquitously expressed. |
| Post-Translational Modification: | Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR. |
| Cellular Location: | Cytoplasm. Cell membrane. Membrane > Clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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