产品详情
简单介绍：
Anti-ERβ Antibody
详情介绍：
Overview
| Name: | Anti-ERβ Antibody See all ERβ primary antibodies
|
| Description: | Rabbit polyclonal antibody to ERβ |
| Specificity: | ERβ Polyclonal Antibody detects endogenous levels of ERβ protein. |
| Applications: | WB, IF, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human ERβ around the non-phosphorylation site of S105. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1mg / ml |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20˚C / 1 year |
Target
| Function: | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
| Tissue Specificity: | Isoform 1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4 is found in testis. Isoform 5 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. |
| Sequence Similarities: | Belongs to the nuclear hormone receptor family. NR3 subfamily. |
| Post-Translational Modification: | Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. |
| Cellular Location: | Nucleus. |
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