产品详情
简单介绍：
Anti-ESX1 Antibody
详情介绍：
Overview
| Name: | Anti-ESX1 Antibody See all ESX1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to ESX1 |
| Applications: | E, WB, IHC |
| Reactivity: | Human |
| Immunogen: | Raised against a 19 amino acid peptide near the center of human ESX1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Affinity chromatography purified via peptide column |
| Formulation: | Supplied in PBS containing 0.02% sodium azide. |
| Storage: | Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Target
| Function: | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Tissue Specificity: | Expressed in placenta and testis. Expressed in testicular germ cell tumors. |
| Post-Translational Modification: | Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C). |
| Cellular Location: | Cytoplasm. Nucleus. ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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