产品详情
简单介绍：
Anti-ETFB Antibody
详情介绍：
Overview
| Name: | Anti-ETFB Antibody See all ETFB primary antibodies
|
| Description: | Rabbit polyclonal antibody to ETFB |
| Specificity: | The antibody detects endogenous levels of total ETFB protein. |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human ETFB |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification |
| Concentration: | 0.4mg / ml |
| Formulation: | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). |
| Tissue Specificity: | Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas. |
| Involvement in Disease: | Glutaric aciduria 2B: An autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. |
| Sequence Similarities: | Belongs to the ETF beta-subunit/FixA family. |
| Post-Translational Modification: | Methylated. Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from Acyl-CoA dehydrogenases. |
| Cellular Location: | Mitochondrion matrix. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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