产品详情
简单介绍：
Anti-ETS1 (A32) Antibody
详情介绍：
Overview
| Name: | Anti-ETS1 (A32) Antibody See all ETS1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to ETS1 (A32) |
| Specificity: | ETS1 (A32) pAb detects endogenous levels of ETS1 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide, corresponding to the N-terminus of Human ETS1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 52 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. |
Target
| Function: | Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. |
| Tissue Specificity: | Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in ***** tissues. None is detected in brain or kidney. |
| Sequence Similarities: | Belongs to the ETS family. |
| Post-Translational Modification: | Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity. |
| Cellular Location: | Cytoplasm. Nucleus. Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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