产品详情
简单介绍：
Anti-F-box only protein 2 Antibody
详情介绍：
Overview
| Name: | Anti-F-box only protein 2 Antibody See all F-box only protein 2 primary antibodies
|
| Description: | Rabbit polyclonal antibody to F-box only protein 2 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide contain a sequence corresponding to a region within amino acids 234 and 296 of F-box only protein 2 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Purified by antigen-affinity chromatography. |
| Formulation: | Supplied in 1XPBS, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. |
| Storage: | Store at -20?C for long term preservation (recommended). Store at 4?C for short term use. |
Target
| Function: | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). |
| Cellular Location: | Cytoplasm. Microsome membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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