产品详情
简单介绍：
Anti-F13A1 Antibody
详情介绍：
Overview
| Name: | Anti-F13A1 Antibody See all F13A1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to F13A1 |
| Specificity: | The antibody detects endogenous levels of total F13A1 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to residues near the C terminal of human Coagulation factor XIII, A1 polypeptide |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 0.5mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
| Involvement in Disease: | Factor XIII subunit A deficiency: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. |
| Sequence Similarities: | Belongs to the transglutaminase superfamily. Transglutaminase family. |
| Post-Translational Modification: | The activation peptide is released by thrombin. |
| Cellular Location: | Cytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. |
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