产品详情
简单介绍：
Anti-F3 Antibody
详情介绍：
Overview
| Name: | Anti-F3 Antibody See all F3 primary antibodies
|
| Description: | Rabbit polyclonal antibody to F3 |
| Specificity: | The antibody detects endogenous level of total F3 protein. |
| Applications: | E, WB, IHC |
| Dilutions: | ELISA: 1:1000-1:2000 Western blotting: 1:200-1:1000 Immunohistochemistry: 1:25-1:100 |
| Reactivity: | Human |
| Immunogen: | Fusion protein corresponding to a region derived from 33-251 amino acids of human coagulation factor III (thromboplastin, tissue factor) |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Predicted MW: | 33kd |
| Formulation: | Supplied at 0.8mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol. |
| Storage: | Store at -20?C / 1 year |
Target
| Background: | This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. |
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