产品详情
简单介绍：
Anti-F7 Antibody
详情介绍：
Overview
| Name: | Anti-F7 Antibody See all F7 primary antibodies
|
| Description: | Rabbit polyclonal antibody to F7 |
| Specificity: | The antibody detects endogenous levels of total F7 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein corresponding to residues near the C terminal of human Coagulation factor VII (serum prothrombin conversion accelerator) |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Antigen affinity purification. |
| Concentration: | 1.5mg / ml |
| Formulation: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Storage: | Store at -20?C |
Target
| Function: | Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. |
| Tissue Specificity: | Plasma. |
| Involvement in Disease: | Factor VII deficiency: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. |
| Sequence Similarities: | Belongs to the peptidase S1 family. |
| Post-Translational Modification: | The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. |
| Cellular Location: | Secreted. |
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