产品详情
简单介绍：
Anti-F9 Antibody
详情介绍：
Overview
| Name: | Anti-F9 Antibody See all F9 primary antibodies
|
| Description: | Rabbit polyclonal antibody to F9 |
| Specificity: | F9 pAb detects endogenous levels of F9 protein. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant full length Human F9. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 52 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol. |
Target
| Function: | Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. |
| Tissue Specificity: | Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma. |
| Involvement in Disease: | Hemophilia B: An X-linked blood coagulation disorder characterized by a permanent tendency to hemorrhage, due to factor IX deficiency. It is phenotypically similar to hemophilia A, but patients present with fewer symptoms. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Thrombophilia, X-linked, due to factor IX defect: A hemostatic disorder characterized by a tendency to thrombosis. |
| Sequence Similarities: | Belongs to the peptidase S1 family. |
| Post-Translational Modification: | Activated by factor XIa, which excises the activation peptide (PubMed:9169594, PubMed:1730085). The propeptide can also be removed by snake venom protease (PubMed:20004170, PubMed:20080729). |
| Cellular Location: | Secreted. |
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