产品详情
简单介绍：
Anti-Factor XI Antibody
详情介绍：
Overview
| Name: | Anti-Factor XI Antibody See all Factor XI primary antibodies
|
| Description: | Rabbit polyclonal antibody to Factor XI |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Immunogen: | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 282 of Human F11 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Purification: | Purified by antigen-affinity chromatography. |
| Formulation: | Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. |
| Storage: | Store at -20?C for long term preservation (recommended). Store at 4?C for short term use. |
Target
| Function: | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
| Tissue Specificity: | Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. |
| Involvement in Disease: | Factor XI deficiency: A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. |
| Sequence Similarities: | Belongs to the peptidase S1 family. Plasma kallikrein subfamily. |
| Post-Translational Modification: | N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. |
| Cellular Location: | Secreted. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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